![]() ern India reveals a minimal increase in the cellularity of the lamina propria mucosae, particularly a minimal increase in the number of plasma cells and a slight irregularity in the sur-face colonocytes. ![]() irregular crypt shape or placement, branching, atrophy. of the rectal and colonic mucosa to the gut luminal en-vironment in inhabitants of the tropics). Close attention to the clinical picture and a careful approach to colorectal biopsy assessment by the pathologist should help reduce the chance of misdiagnosis and incorrect management. mucosa on a colonic biopsy in a patient with colitis changed a patients diagnosis from UC to IC. Rarer potential mimics of IBD include common variable immunodeficiency, Behçet’s disease, graft-versus-host disease, endometriosis, and pneumatosis coli. In tuberculosis, they are typically larger and more confluent than in Crohn’s disease and may show necrosis. Granulomas are a feature of Crohn’s disease but can occur in other settings. Other causes include mass lesions and drugs. lymphogranuloma venereum/syphilis, amoebiasis, and HIV. Mucosal changes similar to those of IBD may be the result of various infections, e.g. Another close mimic is diversion proctocolitis, which is easy to diagnose if the history is available but otherwise is often difficult to distinguish from IBD. It often resembles ulcerative colitis (UC), but, unlike UC, it rarely involves the rectum. Diverticular disease-associated colitis, also referred to as ‘segmental colitis,’ is a disorder of unknown etiology that causes a UC-like appearance to the mucosa in the interdiverticular, and. One of the closest mimics is diverticular colitis, a process that occurs adjacent or close to diverticula. Unfortunately, many conditions share histological features with IBD. ![]() basal plasmacytosis, architectural changes, and granulomas. Histological support for a diagnosis of inflammatory bowel disease (IBD) requires characteristic features, e.g.
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